Real were smarting from a surprise 1-1 draw at struggling Elche in their last match and were missing captain Sergio Ramos, who was out with a stomach bug.
Spanish footballer Jose Antonio Reyes has died in a traffic accident, aged 35, his former club Sevilla said.
Barcelona were held 1-1 at home by Napoli in the first leg of their Europa League knockout stage playoff
If two or more clubs are level on points at the end of the group stage, a number of criteria will be taken into consideration to decide the qualifiers for the next round, starting with the head-to-head record among the teams in question. It then goes to superior goal difference and then goals scored in those matches.
Luuk de Jong's first-half header gave Barcelona a 1-0 win at Mallorca
Real Madrid are also only two points behind Atletico while Sevilla are three back in a thrilling four-way tilt, making the Spanish title race the most compelling
Ramos's contract runs out at the end of June and there are only four La Liga games remaining this season.
Another win would confirm that Barca are heading in the right direction after pushing the reset button following the loss of Lionel Messi in the close season due to their financial problems.
Real Madrid continued their march towards a 35th LaLiga title
Bayern Munich's Polish striker Robert Lewandowski won the FIFA Best Men's Player award for 2021 with Barcelona's Spanish midfielder Alexia Putellas winning the FIFA Best Women's Player prize at Monday's ceremony.
Images from the UEFA Champions League matches played on Tuesday night.
With football matches cancelled across Europe to stop the spread of the coronavirus, La Liga players Borja Iglesias and Sergio Reguilon found a novel way to attract 60,000 online fans - by battling out a thrilling Seville derby on the FIFA 20 videogame. Fans in Andalusia suffering from La Liga withdrawal symptoms after Sunday's clash between Sevilla and Real Betis was postponed tuned in for the showdown between Betis's Iglesias and Sevilla's Reguilon on streaming service Twitch.
Messi, who has struggled for form in recent weeks due to a niggling injury, looked on a mission to grab the winner and after twice coming close he completed his treble to put Barca ahead in the 85th minute, reacting quickly to a poor Sevilla clearance to dink the ball over goalkeeper Tomas Vaclik.
A summary of Wednesday night's action in the UEFA Champions League.
Barcelona were drawn in Group E with Bayern Munich, Benfica and Dynamo Kyiv.
Images from football matches played across Europe.
A round-up of Saturday's action in La Liga and the Bundesliga.
Atletico coach Simeone defends VAR for making football fairer
After an even first 45 minutes, strikes from Pablo Sarabia and Wissam Ben Yedder stunned the Catalans and left them needing a second-leg comeback at the Nou Camp for the second consecutive round in the competition.
In the third-tier Europa Conference League, English Premier League club Leicester City will face Danish side Randers and Scottish club Celtic will take on Norwegian champions Bodo/Glimt in the knockout playoff round.
The draw interrupted a run of four straight league wins for Zinedine Zidane's side and left them second on 67 points after 31 games, three behind leaders Atletico who thrashed Eibar 5-0 earlier in the day.
Real are on 81 points with four games to go. They are 17 points ahead of nearest rivals Sevilla.
Manchester United breezed into the next round with a 6-1 aggregate win over Club Brugge
A summary of Saturday's action in the Bundesliga and La Liga.
Barcelona lifted the Spanish Super Cup for a record extending 13th time by coming from behind to beat Sevilla 2-1 on Sunday thanks to a stunning strike from France winger Ousmane Dembele and a penalty save in stoppage time from Marc-Andre ter Stegen.
News of all that's transpired on and off the football field.
The stadiums at Qatar offer plenty of wisdom and chutzpah on how to take our own lives forward.
Shakhtar dominated possession as expected but were toothless up front and Inter opened the scoring with their first chance after 19 minutes.
Ajax forward Quincy Promes got into a fight with one of his relatives there and stabbed him.
La Liga champions Barcelona slumped to a shock 2-1 defeat at struggling Leganes and Real Madrid were resoundingly beaten 3-0 by Sevilla on Wednesday as Spain's two biggest clubs lost on the same day for the first time since January, 2015.
Sevilla became surprise Liga leaders on Sunday after beating visiting Celta Viga 2-1 while champions Barcelona drew 1-1 at Valencia thanks to another Lionel Messi strike but are still without a victory in their last four league games.
'Now we have to look to the next game, which is important for us, in the FA Cup'
Juventus were given a chance to avenge last year's Champions League final defeat by Real Madrid when they two sides were drawn together for the quarter-finals of this year's competition on Friday.
Bayern Munich slumped to a shock 4-1 loss at Hoffenheim in the Bundesliga on Sunday. The defeat ended their 32-match unbeaten run in all competitions stretching back to last year.
A summary of all things football.
Arsenal had scored 10 goals in two matches against BATE Borisov in the same competition in 2017 but never looked like being as prolific in the freezing temperatures of Belarus.
Images from the UEFA Champions League matches played on Wednesday.
A summary of Saturday's action in LaLiga, Ligue 1 and the Bundesliga.
Joaquin, 37, became the oldest scorer in a Seville top-flight derby when he rose to head home at the near post in the 79th minute, shortly after the visitors had had midfielder Roque Mesa sent off for two bookings.
A round-up of Saturday's action in the Premier League.